RxStore-365: Your Comprehensive Pharmaceuticals Guide

Crossover Trial Design: How Bioequivalence Studies Are Structured

Crossover trial design is the gold standard for bioequivalence studies, using each participant as their own control to reduce variability and lower costs. Learn how 2x2 and replicate designs work, when to use them, and why washout periods matter.

Jonathan Neal

Insurance Benefit Design: How Health Plans Use Generics to Cut Costs

Health plans use tiered formularies, step therapy, and PBM contracts to push patients toward generic drugs, saving billions - but hidden pricing practices often prevent patients from seeing those savings. Learn how the system works - and what you can do about it.

Daniel Whittaker

Current Drug Shortages: Which Medications Are Scarce Today in 2025

As of 2025, over 270 medications remain in short supply in the U.S., including IV fluids, chemotherapy drugs, antibiotics, and ADHD medications. Learn which drugs are hardest to find, why shortages persist, and what patients and providers can do.

Jonathan Neal

How to Follow Professional Society Safety Updates on Medications

Learn how to track and act on official medication safety updates from ISMP, FDA, ASHP, and WHO. Stop missing critical alerts and start preventing errors before they happen.

Daniel Whittaker

Goldenseal and Metformin Interaction Risks for Blood Sugar Control

Goldenseal may reduce metformin absorption, raising blood sugar risk in type 2 diabetes. Clinical studies show a dose-dependent interaction that can undermine treatment-especially at low metformin doses. Don't risk your glucose control with herbal supplements.

Daniel Whittaker

SNRI Medications: Extended Treatment Options for Mental Health

SNRI medications like venlafaxine and duloxetine offer effective treatment for depression, especially when paired with chronic pain or fatigue. Learn how they work, how they compare to SSRIs, and who benefits most.

Daniel Whittaker

How to Confirm Monitoring Labs and Follow-Up for Medications

Learn how labs verify and validate medication monitoring tests to ensure accurate dosing. Understand the steps, risks, and questions to ask to protect patients from dangerous errors.

Jonathan Neal

Tramadol and Serotonin Syndrome: What You Need to Know About This Dangerous Interaction

Tramadol can cause serotonin syndrome even at normal doses, especially when taken with antidepressants. Unlike other opioids, it boosts serotonin levels-making it uniquely dangerous. Learn the signs, risks, and safer alternatives.

Daniel Whittaker

Metformin Myths and Facts: Tolerability, B12, and Long-Term Use

Metformin remains the first-line treatment for type 2 diabetes, but myths about stomach issues, B12 loss, and long-term safety persist. Here’s what the science really says about tolerability, vitamin B12, and using metformin for years.

Daniel Whittaker

Benzodiazepines: What They Do, How They Help, and Why They Can Be Dangerous

Benzodiazepines offer fast relief for anxiety and seizures but carry high risks of dependence and withdrawal. Learn how they work, when they're truly helpful, and how to use them safely-or stop them properly.